Education as an investment constitutes the largest enterprise. It is the principal instrument for academic progress, social mobilization, political survival and effective national development of any country. Investment in education is a necessary condition for promotion of economic growth and national development. Quality higher education system will produce quality skills and quality human capacity. Human Resource Development towards National Development. Thus, this article reviewed the literatures on quality administration and management in higher education with the aims of highlighting the implication of human resource development. This study aims at discussing the management of human resources (HR) at Muhammadiyah University, Jakarta, comprises HR planning, recruitment, selection, training and development, compensation, and performance evaluation activities. This study uses a qualitative method with a case study approach. Data collected from document studies, interviews and observation. Human resources are the key to rapid socio-economic development and efficient service delivery. That’s why this paper stressed that without an adequate, skilled and well-motivated workforce operating within a sound human resource management programme, development is not possible. Every educational system at every level depends heavily on the human resources for execution of its programme. The function of human resource management in education includes staff maintenance, staff relations, staff development, procurement of staff and job performance reward. The challenges of human resource management include poor working condition, problem of staffing, funding, incessant transfer of teacher among others. To work in an organization, if ignore from topics theory divisions between management theoretician you need proper programming, organization, leadership, proper human relations, decisions making and goal financial system and precise personnel system. These are very essential and malpractice of any of the above may bring up difficulties in the process of the activities in that organization.