publication . Article . 2021

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF FEXOFENADINE HYDROCHLORIDE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

D.Chinababu, K. Supraveena*;
Open Access
  • Published: 23 Nov 2021
  • Publisher: Zenodo
Abstract
A simple, rapid and accurate method was developed for the determination of Fexofenadine Hydrochloride in bulk and pharmaceutical dosage form by RP-HPLC method using C18 column [4.6×250mm,5μm] in binary gradient mode. The mobile phase consisted of methanol and water in the ratio of 80:20 v/v. The flow rate was maintained at 1.2 mL/min and wavelength was maintained at 220 nm. The column oven temperature was maintained at 40°c. The retention time of Fexofenadine Hydrochloride was attained at 2.96 min. The method was linear over the concentration range from 7.5-40μg/mL and R2 was found to be 0.999. The intraday and interday precision %RSD values were obtained <2....
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