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Publication . Article . Preprint . 2021

The Origins of SARS-CoV-2: A Critical Review

Edward C. Holmes; Stephen A. Goldstein; Angela L. Rasmussen; David Robertson; Alexander Crits-Christoph; Joel O. Wertheim; Simon J. Anthony; +14 Authors
Open Access

The Origins of SARS-CoV-2: A Critical Review Holmes et al. Published online: 18-Aug-2021, Cell, Since the first reports of a novel SARS-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how SARS-CoV-2 emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2. Computer readable versions of data tables, SVG maps, and acknowledgements of sequence data used are available from:

Authors' final peer-reviewed version. Published as:

Subjects by Vocabulary

Medical Subject Headings: viruses virus diseases skin and connective tissue diseases fungi body regions

Microsoft Academic Graph classification: Scientific evidence Biological evolution Population education.field_of_study education Intensive care medicine medicine.medical_specialty medicine 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Coronavirus medicine.disease_cause Biology


sars-cov-2, covid-19, origins, zoonosis, Review, evolution, General Biochemistry, Genetics and Molecular Biology, COVID-19, Coronavirus, 11 Medical and Health Sciences, 06 Biological Sciences, Animals, Biological Evolution, Humans, Laboratories, Zoonoses

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