This review intends to assess the possibilities of novel vesicular drug delivery systems for targeting. Novel drug delivery seeks to either sustain drug action at a predetermined rate or maintain an adequately constant, adequate drug level in the body with associated minimization of unwanted side effects. An NDDS delivers drugs at a fixed rate decided as per the body’s requirement, pharmacological aspects, drug profile, and physiological conditions. In present conditions, not a single novel drug delivery system acts ideally with fewer side effects. The vesicular system's aim in drug delivery has changed the definition of diagnosis and treatment in different biomedical field aspects “A vesicular drug delivery system is the system in which the protection of active ingredients in a vesicular structure which bridges the gap between ideal and availability of novel drug delivery system.” Several vesicular drug delivery systems like Liposomes, Niosomes, Proniosomes, Transferosomes, Pharmacosomes, Colloidosomes, Herbosomes, Sphingosomes, Aquasomes, Ufasomes, and Electrosomes have been developed. This review includes a discussion about various lipoidal and non-lipoidal vesicular drug targeting.