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Charge-Based Separation of Micro- and Nanoparticles

Authors: Ho, Bao Dang; Beech, Jason P.; Tegenfeldt, Jonas O.;

Charge-Based Separation of Micro- and Nanoparticles

Abstract

an important property of micro- and nanoparticles in colloidal or separation science. We also demonstrate proof of principle of separation of nanoscale liposomes of different lipid compositions, with strong relevance for biomedicine. We perform careful characterization of relevant experimental conditions necessary to obtain adequate sorting of different particle types. By choosing a combination of frequency and amplitude, sorting can be made sensitive to the particle subgroup of interest. The enhanced displacement effect due to electrokinetics is found to be significant at low frequency and for particles with high zeta potential. The effect appears to scale with the square of the voltage, suggesting that it is associated with either non-linear electrokinetics or dielectrophoresis (DEP). However, since we observe large changes in separation behavior over the frequency range at which DEP forces are expected to remain constant, DEP can be ruled out.

Deterministic Lateral Displacement (DLD) is a label-free particle sorting method that separates by size continuously and with high resolution. By combining DLD with electric fields (eDLD), we show separation of a variety of nano and micro-sized particles primarily by their zeta potential. Zeta potential is an indicator of electrokinetic charge&mdash

the charge corresponding to the electric field at the shear plane&mdash

Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:Mechanical engineering and machinery lcsh:TJ1-1570

Keywords

charge-based separation, electrokinetic deterministic lateral displacement, TJ1-1570, Mechanical engineering and machinery, Article

103 references, page 1 of 11

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2. Siyang, Z.; Yung, R.; Yu-Chong, T.; Kasdan, H. Deterministic lateral displacement MEMS device for continuous blood cell separation. In Proceedings of the 18th IEEE International Conference on Micro Electro Mechanical Systems, Miami Beach, FL, USA, 30 January-3 February 2005; pp. 851-854.

3. Davis, J.A.; Inglis, D.W.; Morton, K.J.; Lawrence, D.A.; Huang, L.R.; Chou, S.Y.; Sturm, J.C.; Austin, R.H. Deterministic hydrodynamics: Taking blood apart. Proc. Natl. Acad. Sci. USA 2006, 103, 14779-14784. [CrossRef]

4. Li, N.; Kamei, D.T.; Ho, C.M. On-chip continuous blood cell subtype separation by deterministic lateral displacement. In Proceedings of the 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Bangkok, Thailand, 16-19 January 2007; pp. 932-936.

5. Inglis, D.W.; Lord, M.; Nordon, R.E. Scaling deterministic lateral displacement arrays for high throughput and dilution-free enrichment of leukocytes. J. Micromechanics Microengineering 2011, 21, 054024. [CrossRef]

6. Holmes, D.; Whyte, G.; Bailey, J.; Vergara-Irigaray, N.; Ekpenyong, A.; Guck, J.; Duke, T. Separation of blood cells with di ering deformability using deterministic lateral displacement. Interface Focus 2014, 4, 20140011. [CrossRef]

7. Loutherback, K.; D'Silva, J.; Liu, L.; Wu, A.; Austin, R.H.; Sturm, J.C. Deterministic separation of cancer cells from blood at 10 mL/min. AIP Adv. 2012, 2, 42107. [CrossRef]

8. Liu, Z.; Huang, F.; Du, J.; Shu, W.; Feng, H.; Xu, X.; Chen, Y. Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure. Biomicrofluidics 2013, 7, 11801. [CrossRef]

9. Karabacak, N.M.; Spuhler, P.S.; Fachin, F.; Lim, E.J.; Pai, V.; Ozkumur, E.; Martel, J.M.; Kojic, N.; Smith, K.; Chen, P.I.; et al. Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat. Protoc. 2014, 9, 694-710. [CrossRef] [PubMed]

10. Okano, H.; Konishi, T.; Suzuki, T.; Suzuki, T.; Ariyasu, S.; Aoki, S.; Abe, R.; Hayase, M. Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device. Biomed. Microdevices 2015, 17, 9964. [CrossRef] [PubMed]

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