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Article . 2020
License: CC BY
Data sources: Datacite
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Article . 2020
License: CC BY
Data sources: Datacite
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overview of nano emulsions concept formulations and applications

Authors: Dube Shubhada Bhausaheb; Ghumare Rushikesh Ratnakar; Pagar Swati Aappasaheb; Musmade Deepak Sitaram;

overview of nano emulsions concept formulations and applications

Abstract

Nanoemulsions are colloidal dispersion drug delivery systems that are thermodynamically stable, made up of two immiscible liquids mixed along with emulsifying agents (surfactants and co-surfactants) to form a single phase. Nanoemulsions have broadly been studied as drug delivery systems. This review aims to provide detailed information regarding various formulation and characterization methods developed for nanoemulsions. Nanoemulsions are prepared using two different methods, the the Brute force method and persuasion method. Various characterization techniques for nanoemulsions include particle size, polydispersity index, zeta potential determination of entrapment efficiency, as well as characterization through differential scanning calorimetry, Fourier-transform infrared spectroscopy and transmission electron microscopy. Nanoemulsions are further evaluated by studying in vitro drug release, shelf life, dispersibility, viscosity, in vitro permeation, stability and thermodynamic stability, surface tension, friccohesity, refractive index, percent transmittance, pH and osmolarity. The high flexibility of nanoemulsion includes a variety of preparation process options and a combination of widely assorted components such as surfactants, liquid lipids or even drug-conjugates. These features provide novel approach for designing innovative nanoemulsions aiming at high-value applications. This review presents the overview of nanoemulsions with challenges and prospects of different nanoemulsion types and its application.

Keywords

Nanoemulsions, Nanoemulsion Characterization, Entrapment Efficiency, Droplet Size.

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green