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the structure of behavioral variation within a genotype

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 23 Sep 2019 United States Publisher:Cold Spring Harbor LaboratoryJournal:eLife, volume 10 (eissn: 2050-084X,

Copyright policy )Funded by:NSF | Graduate Research Fellows..., NIH | A path to personalized ph..., NIH | A Modular Automated Platf...

Authors: Werkhoven, Zach; Bravin, Alyssa; Skutt-Kakaria, Kyobi; Reimers, Pablo; Pallares, Luisa; Ayroles, Julien; de Bivort, Benjamin;

doi: 10.1101/779363 , 10.7554/elife.64988 , 10.5281/zenodo.4081667 , 10.5281/zenodo.4110049 , 10.5281/zenodo.4081666

pmid: 34664550

pmc: PMC8526060

the structure of behavioral variation within a genotype

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Abstract

AbstractIndividual animals vary in their behaviors. This is true even when they share the same genotype and were reared in the same environment. Clusters of covarying behaviors constitute behavioral syndromes, and an individual’s position along such axes of covariation is a representation of their personality. Despite these conceptual frameworks, the structure of behavioral covariation within a genotype is essentially uncharacterized and its mechanistic origins unknown. Passing hundreds of inbredDrosophilaindividuals through an experimental pipeline that captured hundreds of behavioral measures, we found correlations only between sparse pairs of behaviors. Thus, the space of behavioral variation has many independent dimensions. Manipulating the physiology of the brain, and specific neural populations, altered specific correlations. We also observed that variation in gene expression can predict an individual’s position on some behavior axes. This work represents the first steps in understanding the biological mechanisms determining the structure of behavioral variation within a genotype.

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Keywords

570, covariation, Behavior, Animal, Genotype, QH301-705.5, Science, invdividuality, Q, R, Genetics and Genomics, transcriptomics, Drosophila melanogaster, personality, high-throughput behavior, individuality, personality, covariation, neural circuits, isogenic animals, Drosophila melanogaster, Medicine, Animals, high-throughput behavior, Biology (General), neural circuits

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