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Eradicate Coronavirus by blocking replication, counteracting its defense system

Name: Eradicate Coronavirus by blocking replication, counteracting its defense system
Creator: Smith, Kira
Keywords: p53, Respiratory Tract Diseases, Other Medical Specialties, HIF-1α, Infectious Disease, Diseases, Social and Behavioral Sciences, Eradicate Coronavirus, Covid, Lysosomotropic

descriptionPublicationkeyboard_double_arrow_right Article , Preprint , Research , Other literature type 05 Aug 2020Publisher:Center for Open Science

Authors: Smith, Kira;

doi: 10.31237/osf.io/y4cbt , 10.31229/osf.io/479z3 , 10.31219/osf.io/psz35 , 10.6084/m9.figshare.12756131 , 10.6084/m9.figshare.12756131.v4 , 10.5281/zenodo.4078211 , 10.5281/zenodo.3974588 , 10.5281/zenodo.4078212 , 10.5281/zenodo.3974339 , 10.5281/zenodo.3971127 , 10.5281/zenodo.3988761 , 10.6084/m9.figshare.12756131.v5 , 10.5281/zenodo.3973628 , 10.5281/zenodo.3976104 , 10.6084/m9.figshare.12756131.v6 , 10.6084/m9.figshare.12756131.v3 , 10.6084/m9.figshare.12756131.v7

Eradicate Coronavirus by blocking replication, counteracting its defense system

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Abstract

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

Related Organizations

University of Eastern Piedmont Amadeo Avogadro
Italy

Keywords

p53, Respiratory Tract Diseases, Other Medical Specialties, HIF-1α, Infectious Disease, Diseases, Social and Behavioral Sciences, Eradicate Coronavirus, Covid, Lysosomotropic, SIRT1, Coronavirus replication, Cytokines Storm, Medicine and Health Sciences, Medical Specialties, Autophagy, HIF, Tenovin, Covid-19 treatment, Biology, Immunology and Infectious Disease, Sars-Cov-2, SIRT1 inhibitors, Life Sciences, Immunoprophylaxis and Therapy, Other Immunology and Infectious Disease, Coronavirus, Treatment, Immunology of Infectious Disease, Virus Diseases, mTOR, Cytokines, Information Literacy, Archival Science, Covid-19, Library and Information Science

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Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system
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