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Formulasi Sediaan Hidrogel Ekstrak Etil Asetat Bunga Kecombrang (Nicolaia speciosa) Dengan Basis HPMC dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus
Khairani, Inas; Nuryanti; Sunarto;
Khairani, Inas; Nuryanti; Sunarto;
Formulasi Sediaan Hidrogel Ekstrak Etil Asetat Bunga Kecombrang (Nicolaia speciosa) Dengan Basis HPMC dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus
Bunga kecombrang (Nicolaia speciosa) memiliki kandungan kimia alkaloid, triterpenoid, steroid, flavonoid, dan polifenol yang memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk memformulasikan ekstrak etil asetat bunga kecombrang dengan basis HPMC menjadi sediaan hidrogel yang stabil secara fisik dan melihat aktivitasnya terhadap bakteri Staphylococcus aureus. Bunga kecombrang diekstraksi secara maserasi bertingkat menggunakan pelarut n-heksan dan etil asetat. Gel ekstrak bunga kecombrang dibuat dengan variasi konsentrasi HPMC 3%, 5%, 8%, dan 10% b/b. Formula terbaik yang memenuhi syarat evaluasi uji sifat fisik dan stabil kemudian diuji aktivitas antibakterinya terhadap Staphylococcus aureus menggunakan metode difusi sumuran. Hasil penelitian menunjukkan bahwa perbedaan konsentrasi HPMC dapat mempengaruhi sifat fisik dan kestabilan hidrogel. Formula 1 adalah terbaik yang memenuhi syarat sifat fisik dan stabilitas sediaan dengan pH 5, viskositas 265.900-383.400 cps, daya sebar 4,67-5,20 cm, dan daya lekat 4,01-11,31 detik. Formula 1 menunjukkan aktivitas antibakteri dengan zona hambat sebesar 3,89 mm.
Nicolaia speciosa, hidrogel, HPMC
Nicolaia speciosa, hidrogel, HPMC
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average views 66 downloads 53 citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average - 66views53downloads
popularity
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Bunga kecombrang (Nicolaia speciosa) memiliki kandungan kimia alkaloid, triterpenoid, steroid, flavonoid, dan polifenol yang memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk memformulasikan ekstrak etil asetat bunga kecombrang dengan basis HPMC menjadi sediaan hidrogel yang stabil secara fisik dan melihat aktivitasnya terhadap bakteri Staphylococcus aureus. Bunga kecombrang diekstraksi secara maserasi bertingkat menggunakan pelarut n-heksan dan etil asetat. Gel ekstrak bunga kecombrang dibuat dengan variasi konsentrasi HPMC 3%, 5%, 8%, dan 10% b/b. Formula terbaik yang memenuhi syarat evaluasi uji sifat fisik dan stabil kemudian diuji aktivitas antibakterinya terhadap Staphylococcus aureus menggunakan metode difusi sumuran. Hasil penelitian menunjukkan bahwa perbedaan konsentrasi HPMC dapat mempengaruhi sifat fisik dan kestabilan hidrogel. Formula 1 adalah terbaik yang memenuhi syarat sifat fisik dan stabilitas sediaan dengan pH 5, viskositas 265.900-383.400 cps, daya sebar 4,67-5,20 cm, dan daya lekat 4,01-11,31 detik. Formula 1 menunjukkan aktivitas antibakteri dengan zona hambat sebesar 3,89 mm.
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