Recently a new class of two-dimensional (2D) nanomaterials, called MXenes, was discovered. MXenes are transition metal carbides or nitrides produced by etching of the A element from the MAX phases. MXenes behave as “conductive clays” because of the combination of the metallic conductivity of transition metal carbides and the hydrophilic nature of their hydroxyl or oxygen terminated surfaces. MXenes have already found various applications from electromagnetic interference shielding, energy storage, to antibacterial coatings, and water purification. However, the possibilities of this material as a filler for nano-engineered structural polymer composites have not been studied yet, but these opportunities of MXenes are very promising and relevant. This study is addressed to identify a suitable methodology based on finite element (FE) homogenization approach for prediction of mechanical properties of polymer composite reinforced with MXene 2D nanosheets.