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2D -QSAR STUDY ON SOME NOVEL 6 – ACETYL –3 - [3– CHLORO –2 -(SUBSTITUTED)– 4-OXOAZETIDIN-1-YL]-2, 5-DIPHENYL-2, 3-DIHYDROPYRIDINE-4-CARBONITRILE ANALOGUES AS AN ANTIFUNGAL ACTIVITY

Authors: RiddhiMadhu*1, Sandip Patel2;

2D -QSAR STUDY ON SOME NOVEL 6 – ACETYL –3 - [3– CHLORO –2 -(SUBSTITUTED)– 4-OXOAZETIDIN-1-YL]-2, 5-DIPHENYL-2, 3-DIHYDROPYRIDINE-4-CARBONITRILE ANALOGUES AS AN ANTIFUNGAL ACTIVITY

Abstract

A series of 6-Acetyl-3-[3-Chloro-2-(Substituted)-4-Oxoazetidin-1-yl]-2, 5-Diphenyl-2, 3-Dihydropyridine-4-Carbonitrile were screened for their antifungal activity against fungi Candida albicans. These compounds have showed moderate and very good antifungal activity. The Quantitative Structure Activity-Relationships (QSAR) study on the pyridine series was made using lipophilic, electronic and steric parameters. Several statistical expressions were developed and best models were validated. The studies confirm that the antifungal activity is dependent on selected lipophilic and electronic parameters. The study suggests that substitution on R1 group with increasing lipophilic nature and decreasing electronic factor favorable for antifungal activity. The QSAR study provides important structural insights in designing of potent antimicrobial agents.

Keywords

QSAR, Antimicrobial Agents, Pyridine, Multiple Linear Regression.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green