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Purification of more ACVR1, some crystal hits, and a few fine screens

descriptionPublicationkeyboard_double_arrow_right Preprint 05 Oct 2018Publisher:Zenodo

Authors: Adamson, Roslin; Brennan, Paul; Mateucci, Mizio; Bullock, Alex;

doi: 10.5281/zenodo.1446500 , 10.5281/zenodo.1446499

Purification of more ACVR1, some crystal hits, and a few fine screens

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Abstract

The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA Darmstadt Germany, MSD, Novartis Pharma AG, Ontario Ministry of Economic Development and Innovation, Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome [106169/ZZ14/Z].

Purification protocol for ACVR1, crystal screens with M4K compounds and fine screens of hits.

Related Organizations

University of Oxford
United Kingdom

Keywords

ACVR1, ALK2, crystallisation, purification

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