Niosomes are microscopic vesicles of non-ionic surfactant that are created when the surfactant self- assembles. One intriguing novel drug delivery strategy is niosomal delivery. Liposomes and niosomes are different chemically, yet they share comparable morphological characteristics. Non-ionic surfactants form niosomal vesicles, while lipids form liposomal vesicles. Because surfactants have a stronger chemical stability than lipids, niosomes are superior than liposomes. The notion of niosomes, their benefits advantages, disadvantage, and their composition, their preparation process, the variables affecting niosomal formulation and characterisation, and their applications are the main topics of this review paper. Numerous illnesses, including Parkinson's disease, cancer, migraines, psoriasis, and leishmaniasis, can be treated with niosomes. Niosomes are a useful tool for diagnosis.