The university-business cooperation guidelines provide the basis for the cooperation in the European PhD Hub. The guidelines tackle challenges found in university-business cooperation, in particular, when it comes to the implementation of collaborative doctoral programmes. The document analyses the conditions, and strategies to achieve fruitful cooperation between companies, universities and PhD students. It contains examples on how to assess universities’ innovative potential, establish a business contract and property rights, select PhD students and industrial supervisors and find funding opportunities. The European PhD Hub connects universities, students and business at local and European level via an online platform for research and innovation.