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FORMULATION DESIGN, EVALUATION AND OPTIMIZATION OF CIPROFLOXACIN HCL FLOATING TABLET USING DESIGN EXPERT®

Authors: Khushal*, Dr. Revathi A. Gupta, Shivangni Rathore;

FORMULATION DESIGN, EVALUATION AND OPTIMIZATION OF CIPROFLOXACIN HCL FLOATING TABLET USING DESIGN EXPERT®

Abstract

Floating drug delivery systems have a lower bulk density than gastric fluids and hence remain buoyant in the stomach for an extended period of time without influencing gastric emptying rate. While the system is floating on the gastric contents, the drug is slowly released from the system at the prescribed pace; after drug release, the remaining system is evacuated from the stomach. This leads in extended stomach retention time and better regulation of plasma medication concentration variations. There are two types of floating medication delivery systems. Non-effervescent and Gas-generating systems. Ciprofloxacin HCl floating tablets by using polymers like HPMC K4M, Eudragit 100S, guar gum. The prepared tablets are characterized by using different evaluation parameters like buoyancy lag time, floating time, in-vitro drug release, uniformity of drug content, hardness, friability etc. and it is optimized by factorial design using Design Expert Software. The in-vitro drug release of the optimized formulation is best fitted and found to follow Hixon crowell erosion kinetics with a higher R2 value of 0.992.

Keywords

Ciprofloxacin, Floating Tablet, Gastric Emptying Rate, Control Release, Optimization.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green