This research project of validating the philosophical principles of physis, temperament, humours, and lifestyle factors within the context of aetiology, pathology, diagnosis, and treatment, has been completed in fifty (50) case studies with emphasis on diagnosis based on the role of lifestyle, the predisposition to illness conditions in relation to the temperamental combination and dominant quality, qualitative and humoral imbalances, interpreted accordingto pathological processes and pathways in Tibb diagnosis, and identifying the cause/s of illness conditions. With respect to treatment, the comprehensive understanding of the pathological processes in Tibb allows for an accurate diagnosis, facilitating a targeted approach in treatment, to restore qualitative and humoral balance with diet, herbal medication, and cupping where applicable, has been successful in almost all the case studies.In addition, the research also confirmed the weakening of physis and the development of excess/abnormal Melancholic humours from the age of 40 onwards, as being the cause/s of illness conditions. The holistic approach of the research is in keeping with the Medicine of Hippocrates, Galen, and Ibn Sinathat has been practiced for centuries and also includes information on the differences between herbal and Western medication.