Small, mesh-like structures called nanosponges have a size range of less than 1 m. They can readily bind poorly soluble pharmaceuticals because of their small size and porous structure, which improves the solubility and, in turn, the bioavailability of the same drugs.Both lipophilic and hydrophilic drugs can be loaded into nanosponges. Nanosponges play a major role in targeting drug delivery systems. These can move through the body until they come into contact with the intended target spot, where they adhere to the surface and start to release the medicine in a regulated and predictable manner.The application of nanosponges, its preparation processes, and assessment criteria have been covered in this review article. Nanosponges are solid by nature and can be produced as oral, parenteral, topical, or inhalation dosage forms. Keywords: Nanosponge , Drug delivery , Therapeutic applications.