A novel corona virus (SARS-CoV-2) outbreak is claiming thousands of lives worldwide. As of April 10, 2020, the number of laboratory-confirmed cases of SARS-CoV-2 infected has reached over 1.7 million (1,725,126) with over 0.1 million (104,878) recorded deaths. This pandemic has ushered an urgent need for identifying drugs which can inhibit the survival of SARS-CoV-2. On one hand, researchers from across globe are searching for various sources of potential antiviral compounds. On the other hand, high diversity, ecological adaptation, defensive system against wide range of viruses makes marine bivalves as a great source of antiviral compounds. Ocean environment has provided a rich diversity of compounds from structural classes including alkaloids, terpenoids, steroids, polysaccharides, and peptides etc., many of which have shown potential activities against bacterial, fungal, parasitic and viral diseases. In this scenario, potential antiviral compounds from marine bivalves, worth evaluating against SARS-CoV-2 have been briefly summarized in this present review.