Political instability is a common phenomenon in developing countries. In countries like Ethiopia where democracy is infant and the ruling government dominates the people by all means; strike, mass protest, demonstration and conflict are common features of the country. The oppressed Amhara people infuriate and revolt against TPLF dominated Ethiopian government. This article tries to investigate the causes of political instability in Amhara region, Ethiopia. The paper is qualitative type and data collected through interview and literature review. The study revealed that, the 1976 manifesto prepared by Tigray People Liberation Front (TPLF) labeled as the Amhara people number one enemy for the people of Tigray and decided that the Amhara must be controlled and eliminated. Thus, after taking power in 1991, TPLF have been doing all evil things against the Amhara people by using several techniques. This situation angered the Amhara people and political instability erupted across the region to end TPLF oppression.