The RNA World hypothesis posits that RNA alone could sustain early life as both genetic and catalytic molecule. We challenge this by simulating a minimal 170-nt RNA protocell (70 nt functional + 100 nt rRNA; 30% A, 30% G, 20% C, 15% U, 5% inosine/pseudouridine; ΔΔG -8.5 to -9.5 kcal/mol) in hydrothermal vents (80 ± 15°C, pH 6.0 ± 0.5, oxidative stress 0.45 ± 0.18 mM), ice (-5 ± 3°C, pH 7.0 ± 0.4, oxidative stress 0.08 ± 0.04 mM), and wet-dry cycles (25 ± 10°C, pH 6.8 ± 0.6, oxidative stress 0.35 ± 0.15 mM), excluding all other elements (peptides, DNA, vesicles, catalysts, energy). An Agent-Based Model (ABM) with 1,000 protocells over 100,000 steps (~100 division cycles) and 1,500 replicates reveals rapid collapse: median survival of 30,000–60,000 steps, proto-translation rates of 0.003–0.006 mM/hr, RNA mutation rates of 4.5–5.0 × 10⁻⁷, and lineage divergence of 30–40%. Statistical analyses (ANOVA, regression, Kaplan-Meier, bootstrap) confirm robust failure (p 0.85, 95% CI ±1.5–2.5%), with ice environments marginally better but insufficient. Compared to supported models (970,000 steps, 0.068 mM/hr), RNA-only systems are 94–97% less viable. These extensive simulations statistically refute the RNA World hypothesis, supporting the Matter World Hypothesis (MWH) that molecular synergy is essential. Results are computational and require experimental validation.