Syphilis is an infectious disease with mucocutaneous lesions that are characteristic of their stage (primary, secondary, or tertiary). These are not always typical and may have other morphologies and unusual symptoms, making diagnosis difficult. The report herein is of a healthy woman with vesicular lesions associated with intense itching. The diagnosis of secondary syphilis was confirmed with VDRL 1/512 and FTA Abs positive. Histopathology showed spongiosis in the epidermis and infiltrated lymphocytes and plasma cell in the dermis. Clinical improvement occurred after the first dose of benzathine penicillin. In the literature, few cases of vesicular lesions in syphilis have been found and itching is mentioned as uncharacteristic . Histology showing spongiosis is also unusual.