publication . Article . 2020

Coronavirus disease 2019 (COVID-19) and immune-mediated inflammatory rheumatic diseases: at the crossroads of thromboinflammation and autoimmunity

E. L. Nasonov; T. V. Beketova; Tatiana Reshetnyak; A. Lila; L. P. Ananieva; T. A. Lisitsyna; S. K. Soloviev;
Open Access Russian
  • Published: 04 Sep 2020 Journal: Научно-практическая ревматология, volume 58, issue 4, pages 353-367 (issn: 1995-4484, eissn: 1995-4492, Copyright policy)
  • Publisher: IMA-PRESS LLC
Abstract
<jats:p>Inflammation and coagulation are key basic mechanism of protection against all potentially pathogenic mechanical and biological factors targeting human organism from inner and outer environment. On the other hand, uncontrolled inflammation results in hypercoagulation, inhibition of anticoagulation and alteration of mechanisms responsible for resolution of inflammation, while production of “procoagulant” mediators (thrombin, tissue factor and others), activation of platelets and of vascular endothelial cells maintains inflammation. All factors taken together serve as the basis for a pathological process called thromboinflammation or immunothrombosis. Curr...
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Subjects
free text keywords: thromboinflammation, covid-19, immune-mediated inflammatory rheumatic diseases, coagulopathy, lcsh:Diseases of the musculoskeletal system, lcsh:RC925-935, Complement system, Autoimmunity, medicine.disease_cause, medicine, Tissue factor, Biomarker (medicine), Inflammation, medicine.symptom, Immune system, business.industry, business, Immunology, Proinflammatory cytokine, Coagulopathy, medicine.disease
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