Chromosome cohesion and the spindle checkpoint
Copyright policy )Chromosome cohesion and the spindle checkpoint
Accurate chromosome segregation constitutes the basis of inheritance. Mistakes in chromosome segregation during mitosis lead to aneuploidy, a common feature of tumors. The accuracy of chromosome segregation is governed by a complex network of processes which ensure that each daughter cell receives the correct number of chromosomes. Herein we review recent developments in the understanding of chromosome segregation, focusing on the cohesion that holds the sister chromatids together and the spindle checkpoint which regulates anaphase onset.
- The University of Texas Southwestern Medical Center United States
Cdc20 Proteins, Chromosomal Proteins, Non-Histone, Calcium-Binding Proteins, Mitosis, Cell Cycle Proteins, Repressor Proteins, Chromosome Segregation, Mad2 Proteins, Humans, Anaphase, Cohesins
Cdc20 Proteins, Chromosomal Proteins, Non-Histone, Calcium-Binding Proteins, Mitosis, Cell Cycle Proteins, Repressor Proteins, Chromosome Segregation, Mad2 Proteins, Humans, Anaphase, Cohesins
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