field with online, open access to highly relevant scholarly articles by leading international researchers. In a field where the literature is ever-expanding, researchers increasingly need access to up-to-date, high quality scholarly articles on areas of specific contemporary interest. This supplement aims to address this by presenting high-quality articles that allow readers to distinguish the signal from the noise. The editor in chief hopes that through this effort, practitioners and researchers will be aided in finding answers to some of the most complex and pressing issues of our time. At the discretion of the guest editors other articles on other relevant topics within the scope of the supplement may be included. This supplement is intended to focus on RNA sequence analysis. Topics of interest include, but are not limited to, the following: Data preprocessing and mappingHybrid Computing § § Gene expression § § Novel genes and transcripts discovery and De novo § § transcript assembly Alternative splicing § § RNA editing § § Single nucleotide variation discovery § § Fusion gene detection § § Coexpression networks § § Pathway and master regulator analysis § §