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Antidiarrheal activity of Capparis zeylanica leaf extracts

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2011 English Publisher:MedknowJournal:Journal of Advanced Pharmaceutical Technology & Research, volume 2, page 39 (issn: 2231-4040,

Authors: Barij Nayan Sinha; Karanayil R. Sini; Aiyolu Rajasekaran;

doi: 10.4103/2231-4040.79803

pmid: 22171290

pmc: PMC3217678

Antidiarrheal activity of Capparis zeylanica leaf extracts

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Abstract

The antidiarrheal activity of the methanolic extract of the leaves of Capparis zeylanica (Capparidaceae) was investigated by castor oil-induced diarrhea and small intestine transit method on mice. Like loperamide (3 mg/kg body weight), C. zeylanica methanolic extract (100,150,200 mg/kg body weight) produced a significant decrease in the severity of diarrhea. The percentage protection in extract-treated animals showing diarrhea was compared with castor oil-treated and loperamide-treated animals. The activity was found to be dose-dependant. Its effect when evaluated on intestinal transit produced a decrease in intestinal transit (75.97%).The results revealed that the methanolic extract significantly reduced diarrhea in mice with reduction in weight of stools.

Related Organizations

Grace College & Seminary
United States
Birla Institute of Technology, Mesra
India

Keywords

RS1-441, Pharmacy and materia medica, loperamide, Capparis zeylanica, intestinal transit, castor oil, Original Article, Therapeutics. Pharmacology, RM1-950

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