Guidelines to prevent cross contamination with infectious agents have been instituted for dental clinical and laboratory procedures. However, compliance by dental offices and clinics in disinfecting impression material has not been universal. Techniques for disinfecting impression materials are spraying or immersing impression materials. These techniques can reduce the surface detail and dimensional accuracy of impressions; most disinfectants are irritants. This study reviewed whether antimicrobial activity can be achieved by mixing certain drugs with the impression material and their effects on the disinfection are achieved through such additions.