publication . Article . 2011

Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus

B. G. Adleyba; G. V. Gavrilov; A. V. Stanishevsky; B. V. Gaydar; D. V. Svistov; V Yu Lobzin; K A Kolmakova;
Open Access Russian
  • Published: 01 Jun 2011 Journal: Nevrologiâ, Nejropsihiatriâ, Psihosomatika, volume 11, issue 1, pages 53-58 (issn: 2074-2711, eissn: 2310-1342, Copyright policy)
  • Publisher: IMA-PRESS LLC
  • Country: United States
Abstract
The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) presents difficulties because of the same symptomatology in neurodegenerative diseases. The data of brain magnetic resonance imaging (MRI) and invasive techniques (tap test, external lumbar drainage, and infusion test) not always allow an accurate diagnosis of iNPH, especially when patients have comorbidity. This increases the role of cerebrospinal fluid (CSF) biomarkers in the differential diagnosis of iNPH and comorbidities at early stages. Objective : to analyze the data available in the literature on current ideas about CSF biomarkers and their role in the differential diagnosis of iNPH and neu...
Subjects
free text keywords: normal pressure hydrocephalus, alzheimer's disease, neurodegeneration, biomarkers, beta-amyloid protein, tau protein, Article Subject, Clinical Study, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, lcsh:Geriatrics, lcsh:RC952-954.6, Differential diagnosis, Lumbar, Vascular dementia, medicine.disease, medicine, Pathology, medicine.medical_specialty, Internal medicine, Gastroenterology, Cerebrospinal fluid, Total tau, (Idiopathic) normal pressure hydrocephalus, Csf biomarkers, business.industry, business, Biomarker (medicine), Normal pressure hydrocephalus, Comorbidity, Disease, Tau protein, biology.protein, biology, Neurodegeneration, Bioinformatics
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