Heterohemoantibodies in Inbred Strains of Mice

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1954 English Publisher:Oxford University Press (OUP)Journal:The Journal of Immunology, volume 72, pages 216-223 (issn: 0022-1767, eissn: 1550-6606,

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Authors: Kurt Stern; Israel Davidsohn;

doi: 10.4049/jimmunol.72.3.216 , 10.4049/jimmunol.72.3.209

Heterohemoantibodies in Inbred Strains of Mice

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Abstract

Summary Titers of immune hemoantibodies in mice of 10 inbred strains revealed characteristic patterns for each strain, with considerable variations between strains. The possible role of genetic, metabolic, and hormonal factors in relation to this difference in response of mice to immunization with hemoantigens was discussed. Among 11 strains tested, all five low-tumor strains showed a high immune response, whereas of six high-tumor or high-leukemia strains, five exhibited a low immune response. A possible interpretation of these findings was presented.

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