This article contributes to an overall understanding of the challenges faced by humanitarian aid international non-government organizations (INGOs) in specific culturally context-sensitive regions of Myanmar. This research is based on a review of literature, relevant case study analysis, and on ten semi-structured interviews with the humanitarian activists of the Myanmar Diaspora in Canada. The author investigates the following research question: To what extent does “cultural context” play a crucial role in managing humanitarian aid during disaster response operations in a given affected area, and how does it consequently link to the challenges of humanitarian aid INGOs in Myanmar? Based on the findings, a culturally appropriate framework will be introduced for the efficacy of humanitarian aid INGOs when implementing disaster response operations in Myanmar.