Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.
Copyright policy )Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.
Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the sensitivity of targets for killing by the rat effectors isolated from blood and spleen in vitro. Based on these results, we investigated in vivo the possible therapeutic effect of GM2 and IS carried by liposomes during induced rat colorectal carcinogenesis. The reduction of cancer incidence versus the controls (50% vs 88.88%), approached the 5-fluorouracil treatment (41.66%).
- Institute of Microbiology Belarus
- Czech Academy of Sciences Czech Republic
- National Academy of Sciences of Belarus Belarus
Male, Antimetabolites, Antineoplastic, Drug Carriers, Azoxymethane, Oligosaccharides, G(M2) Ganglioside, Rats, Rats, Sprague-Dawley, Antigens, Surface, Liposomes, Carcinogens, Escherichia coli, Animals, Lectins, C-Type, Fluorouracil, Drug Screening Assays, Antitumor, Colorectal Neoplasms, NK Cell Lectin-Like Receptor Subfamily B
Male, Antimetabolites, Antineoplastic, Drug Carriers, Azoxymethane, Oligosaccharides, G(M2) Ganglioside, Rats, Rats, Sprague-Dawley, Antigens, Surface, Liposomes, Carcinogens, Escherichia coli, Animals, Lectins, C-Type, Fluorouracil, Drug Screening Assays, Antitumor, Colorectal Neoplasms, NK Cell Lectin-Like Receptor Subfamily B
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