With the advent of diverse electronics, the available energy may be light, thermal, and mechanical energies. Multieffect coupled nanogenerators (NGs) exhibit strong ability to harvest ambient energy by integrating various effects comprising piezoelectricity, pyroelectricity, thermoelectricity, optoelectricity, and triboelectricity into a standalone device. Interaction of multitype effects can promote energy harvesting and conversion by modulating charge carriers’ behaviour. Multieffect coupled NGs stand for a vital group of energy harvesters, supporting the advances of an electronic device and promoting the resolution of energy crisis. The matchless versatility and high reliability of multieffect coupled NGs make them main candidates for integration in complicated arrays of the electronic device. Multieffect coupled NGs can also be employed as a variety of self-powered sensors due to their rapid response, high accuracy, and high responsivity. This article reviews the latest achievements of multieffect coupled NGs. Fundamentals mainly including basic theory and materials of interest are covered. Advanced device design and output characteristics are introduced. Potential applications are described, and future development is discussed.