publication . Article . 2015

Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France

Guillaume Castel; Mathilde Couteaudier; Frank Sauvage; Jean-Baptiste Pons; Séverine Murri; Angelina Plyusnina; Dominique Pontier; Jean-François Cosson; Alexander Plyusnin; Philippe Marianneau; ...

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Open Access English

Published: 22 Oct 2015

Publisher: HAL CCSD

Summary
References
31

Abstract

Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing piece of the puzzle is the current distribution and the genetic variation of PUUV in France, which has been overlooked until now and remains poorly understood. During a population survey, from 2008 to 2011, bank voles were trapped in eight different forests of France located in areas known to be endemic for NE or in area from where no NE case has been reported until now. Bank voles were tested for immunoglobulin (Ig)G ELISA serology and two seropositive animals for each of three different areas (Ardennes, Jura and Orleans) were then subjected to laboratory analyses in order to sequence the whole S, M and L segments of PUUV. Phylogenetic analyses revealed that French PUUV isolates globally belong to the central European (CE) lineage although isolates from Ardennes are clearly distinct from those in Jura and Orleans, suggesting a different evolutionary history and origin of PUUV introduction in France. Sequence analyses revealed specific amino acid signatures along the N protein, including in PUUV from the Orleans region from where NE in humans has never been reported. The relevance of these mutations in term of pathophysiology is discussed. Peer reviewed

Persistent Identifiers

doi: 10.3390/v7102884

pmc: PMC4632392

pmid: 26506370

Sustainable Development Goals (SDG) [Beta]

2. Zero hunger

Subjects

free text keywords: phylogeny, complete genome, diversity, France, Hantavirus, Puumala virus, [SDV]Life Sciences [q-bio], VIRUS NUCLEOCAPSID PROTEIN, MAJOR ANTIGENIC DOMAIN, BIOINFORMATICS DATABASE, MOLECULAR EVOLUTION, ANALYSIS RESOURCE, STRAINS, TULA, INFECTION, PATTERNS, GENETICS, 3111 Biomedicine, Virology, Infectious Diseases, [SDV] Life Sciences [q-bio], France;Hantavirus;Puumala virus;complete genome;diversity;phylogeny, technique elisa, analyse phylogénétique, campagnol roussatre, diversité génétique, Article, Hantavirus; Puumala virus; complete genome; phylogeny; diversity; France, lcsh:Microbiology, lcsh:QR1-502, Phylogenetics, Virology, Nephropathia epidemica, medicine.disease, medicine, Puumala virus, biology.organism_classification, biology, Bank vole, Genetic variation, Zoology, Disease reservoir, Arvicolinae, Hantavirus

Related Organizations

University of Helsinki
Finland
UNIVERSITE PARIS DESCARTES
France
Physiopathology, metabolism and nutrition
France

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EC| ANTIGONE, EC| EDENEXT, ANR| ECOFECT, ANR| Avenir L.S.E.

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31 references, page 1 of 3

1. Plyusnin, A.; Sironen, T. Evolution of hantaviruses: Co-speciation with reservoir hosts for more than 100 MYR. Virus Res. 2014, 187, 22-26. [CrossRef] [PubMed]

2. Vaheri, A.; Strandin, T.; Hepojoki, J.; Sironen, T.; Henttonen, H.; Mäkelä, S.; Mustonen, J. Uncovering the mysteries of hantavirus infections. Nat. Rev. Microbiol. 2013, 11, 539-550. [CrossRef] [PubMed]

3. Zhang, Y.Z. Discovery of hantaviruses in bats and insectivores and the evolution of the genus Hantavirus. Virus Res. 2014, 187, 15-21. [CrossRef] [PubMed]

4. Jaaskelainen, K.M.; Kaukinen, P.; Minskaya, E.S.; Plyusnina, A.; Vapalahti, O.; Elliott, R.M.; Weber, F.; Vaheri, A.; Plyusnin, A. Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter. J. Med. Virol. 2007, 79, 1527-1536. [CrossRef] [PubMed] [OpenAIRE]

5. Plyusnin, A. Genetics of hantaviruses: Implications to taxonomy. Arch Virol. 2002, 147, 665-682. [CrossRef] [PubMed] [OpenAIRE]

6. Vaheri, A.; Henttonen, H.; Voutilainen, L.; Mustonen, J.; Sironen, T.; Vapalahti, O. Hantavirus infections in Europe and their impact on public health. Rev. Med. Virol. 2013, 23, 35-49. [CrossRef] [PubMed] [OpenAIRE]

7. Olsson, G.E.; Leirs, H.; Henttonen, H. Hantaviruses and their hosts in Europe: Reservoirs here and there, but not everywhere? Vector Borne Zoonot. Dis. 2010, 10, 549-561. [CrossRef] [PubMed] [OpenAIRE]

8. Plyusnin, A.; Vapalahti, O.; Ulfves, K.; Lehväslaiho, H.; Apekina, N.; Gavrilovskaya, I.; Blinov, V.; Vaheri, A. Sequences of wild Puumala virus genes show a correlation of genetic variation with geographic origin of the strains. J. Gen. Virol. 1994, 75, 405-409. [CrossRef] [PubMed]

9. Sironen, T.; Vaheri, A.; Plyusnin, A. Molecular evolution of Puumala hantavirus. J. Virol. 2001, 75, 11803-11810. [CrossRef] [PubMed]

10. Heiske, A.; Anheier, B.; Pilaski, J.; Volchkov, V.E.; Feldmann, H. A new Clethrionomys-derived hantavirus from Germany: Evidence for distinct genetic sublineages of Puumala viruses in Western Europe. Virus Res. 1999, 61, 101-112. [CrossRef]

11. Escutenaire, S.; Chalon, P.; Heyman, P.; van der Auwera, G.; van der Groen, G.; Verhagen, R.; Thomas, I.; Karelle-Bui, L.; Vaheri, A.; Pastoret, P.P.; et al. Genetic characterization of Puumala hantavirus strains from Belgium: Evidence for a distinct phylogenetic lineage. Virus Res. 2001, 74, 1-15. [CrossRef]

12. Plyusnina, A.; Aberle, S.W.; Aberle, J.H.; Plyusnin, A. Genetic analysis of Puumala hantavirus strains from Austria. Scand. J. Infect. Dis. 2006, 38, 512-519. [CrossRef] [PubMed]

13. Razzauti, M.; Plyusnina, A.; Niemimaa, J.; Henttonen, H.; Plyusnin, A. Co-circulation of two Puumala hantavirus lineages in Latvia: A Russian lineage described previously and a novel Latvian lineage. J. Med. Virol. 2012, 84, 314-318. [CrossRef] [PubMed]

14. Asikainen, K.; Hänninen, T.; Henttonen, H.; Niemimaa, J.; Laakkonen, J.; Andersen, H.K.; Bille, N.; Leirs, H.; Vaheri, A.; Plyusnin, A. Molecular evolution of puumala hantavirus in Fennoscandia: Phylogenetic analysis of strains from two recolonization routes, Karelia and Denmark. J. Gen. Virol. 2000, 81, 2833-2841. [CrossRef] [PubMed] [OpenAIRE]

15. Horling, J.; Lundkvist, A.; Jaarola, M.; Plyusnin, A.; Tegelström, H.; Persson, K.; Lehväslaiho, H.; Hörnfeldt, B.; Vaheri, A.; Niklasson, B. Distribution and genetic heterogeneity of Puumala virus in Sweden. J. Gen. Virol. 1996, 77, 2555-2562. [CrossRef] [PubMed]

31 references, page 1 of 3

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