TRPM8 Channels and Dry Eye
Copyright policy )TRPM8 Channels and Dry Eye
Transient receptor potential (TRP) channels transduce signals of chemical irritation and temperature change from the ocular surface to the brain. Dry eye disease (DED) is a multifactorial disorder wherein the eyes react to trivial stimuli with abnormal sensations, such as dryness, blurring, presence of foreign body, discomfort, irritation, and pain. There is increasing evidence of TRP channel dysfunction (i.e., TRPV1 and TRPM8) in DED pathophysiology. Here, we review some of this literature and discuss one strategy on how to manage DED using a TRPM8 agonist.
- University of California System United States
- University of California, Berkeley United States
- University of California, San Francisco United States
- Korea Advanced Institute of Science and Technology Korea (Republic of)
- Chonnam National University Korea (Republic of)
TRPM8, Biomedical and Clinical Sciences, Pain Research, Neurosciences, R, 610, 600, Pharmacology and Pharmaceutical Sciences, Review, dry eye disease, RS1-441, Pharmacology and pharmaceutical sciences, Pharmacy and materia medica, transient receptor potential, TRPV, 2.1 Biological and endogenous factors, Medicine, Chronic Pain, Aetiology, Eye Disease and Disorders of Vision, Ophthalmology and Optometry
TRPM8, Biomedical and Clinical Sciences, Pain Research, Neurosciences, R, 610, 600, Pharmacology and Pharmaceutical Sciences, Review, dry eye disease, RS1-441, Pharmacology and pharmaceutical sciences, Pharmacy and materia medica, transient receptor potential, TRPV, 2.1 Biological and endogenous factors, Medicine, Chronic Pain, Aetiology, Eye Disease and Disorders of Vision, Ophthalmology and Optometry
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