Chemical Reactivity Theory Study of Advanced Glycation Endproduct Inhibitors
Copyright policy )Chemical Reactivity Theory Study of Advanced Glycation Endproduct Inhibitors
Several compounds with the known ability to perform as inhibitors of advanced glycation endproducts (AGE) have been studied with Density Functional Theory (DFT) through the use of anumberofdensityfunctionalswhoseaccuracyhasbeentestedacrossabroadspectrumofdatabases in Chemistry and Physics. The chemical reactivity descriptors for these systems have been calculated through Conceptual DFT in an attempt to relate their intrinsic chemical reactivity with the ability to inhibit the action of glycating carbonyl compounds on amino acids and proteins. This knowledge could be useful in the design and development of new drugs which can be potential medicines for diabetes and Alzheimer’s disease.
Glycation End Products, Advanced, Models, Molecular, Computational chemistry, Organic chemistry, Molecular modeling, Productos Finales de Glicación Avanzada, Article, QD241-441, conceptual DFT, Modelos Químicos, Diseño de Fármacos, Modelos Moleculares, Humans, diabetes, Algoritmos, Molecular Structure, molecular modeling, Diabetes, diabetes; Alzheimer; AGEs inhibitors; computational chemistry; molecular modeling; conceptual DFT; chemical reactivity theory, AGEs inhibitors, computational chemistry, Humanos, Models, Chemical, Conceptual DFT, Estructura Molecular, chemical reactivity theory, Drug Design, Alzheimer, Algorithms, Chemical reactivity theory
Glycation End Products, Advanced, Models, Molecular, Computational chemistry, Organic chemistry, Molecular modeling, Productos Finales de Glicación Avanzada, Article, QD241-441, conceptual DFT, Modelos Químicos, Diseño de Fármacos, Modelos Moleculares, Humans, diabetes, Algoritmos, Molecular Structure, molecular modeling, Diabetes, diabetes; Alzheimer; AGEs inhibitors; computational chemistry; molecular modeling; conceptual DFT; chemical reactivity theory, AGEs inhibitors, computational chemistry, Humanos, Models, Chemical, Conceptual DFT, Estructura Molecular, chemical reactivity theory, Drug Design, Alzheimer, Algorithms, Chemical reactivity theory
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