Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice
Copyright policy )Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice
In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated in mice exposed to scopolamine. Our results demonstrated that chronic oral administration (28 days) of DMC (10 mg/kg) improved scopolamine-induced learning impairment in the passive avoidance task and memory impairment in the Morris water maze. Moreover, Choline acetyltransferase (ChAT) activity in the DMC-treated group was significantly increased to 33.03% compared with the control group. Our present finding suggests that DMC ameliorates memory impairments induced by scopolamine treatment through reversing the reduction of hippocampal ChAT expression in mice.
- Korea Food Research Institute Korea (Republic of)
- Korea University of Science and Technology Korea (Republic of)
Male, Curcumin, demethoxycurcumin, Scopolamine, Organic chemistry, Administration, Oral, Drug Administration Schedule, scopolamine, Choline O-Acetyltransferase, Mice, QD241-441, Diarylheptanoids, Avoidance Learning, Animals, Maze Learning, passive avoidance task, Memory Disorders, Mice, Inbred ICR, Communication, Disease Models, Animal, acetyltransferase, Gene Expression Regulation, Morris water maze
Male, Curcumin, demethoxycurcumin, Scopolamine, Organic chemistry, Administration, Oral, Drug Administration Schedule, scopolamine, Choline O-Acetyltransferase, Mice, QD241-441, Diarylheptanoids, Avoidance Learning, Animals, Maze Learning, passive avoidance task, Memory Disorders, Mice, Inbred ICR, Communication, Disease Models, Animal, acetyltransferase, Gene Expression Regulation, Morris water maze
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