Actions
  • shareshare
  • link
  • cite
  • add
add
auto_awesome_motion View all 4 versions
Publication . Article . Other literature type . 2014

Targeting Nuclear Receptors with Marine Natural Products

Chunyan Yang; Qianrong Li; Yong Li;
Open Access
English
Published: 01 Jan 2014 Journal: Marine Drugs, volume 12, issue 2, pages 601-635 (eissn: 1660-3397, Copyright policy )
Publisher: MDPI
Country: France
Abstract
Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal role in modulating nuclear receptor activity, the discovery of novel ligands for nuclear receptors represents an interesting and promising therapeutic approach. The search for novel NR agonists and antagonists with enhanced selectivities prompted the exploration of the extraordinary chemical diversity associated with natural products. Recent studies involving nuclear receptors have disclosed a number of natural products as nuclear receptor ligands, serving to re-emphasize the translational possibilities of natural products in drug discovery. In this review, the natural ligands of nuclear receptors will be described with an emphasis on their mechanisms of action and their therapeutic potentials, as well as on strategies to determine potential marine natural products as nuclear receptor modulators.
Subjects by Vocabulary

Microsoft Academic Graph classification: Nuclear receptor Small heterodimer partner Computational biology Constitutive androstane receptor Biology Receptor Pregnane X receptor Biochemistry Chemical diversity Drug discovery Aquatic organisms

Library of Congress Subject Headings: lcsh:Biology (General) lcsh:QH301-705.5

Subjects

Review, nuclear receptors, marine natural products, ligands, screen, drug targets, nuclear receptors, marine natural products, ligands, screen, drug targets, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pharmaceutical Science

Related Organizations
236 references, page 1 of 24

Koehn, F.E., Carter, G.T.. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov.. 2005; 4: 206-220 [OpenAIRE] [PubMed] [DOI]

Miljanich, G.P.. Ziconotide: Neuronal calcium channel blocker for treating severe chronic pain. Curr. Med. Chem.. 2004; 11: 3029-3040 [OpenAIRE] [PubMed] [DOI]

Molinski, T.F., Dalisay, D.S., Lievens, S.L., Saludes, J.P.. Drug development from marine natural products. Nat. Rev. Drug Discov.. 2009; 8: 69-85 [OpenAIRE] [PubMed] [DOI]

Trabectedin: Ecteinascidin 743, Ecteinascidin-743, ET 743, ET-743, NSC 684766. Drugs R D. 2006; 7: 317-328 [OpenAIRE] [PubMed] [DOI]

Overington, J.P., Al-Lazikani, B., Hopkins, A.L.. How many drug targets are there?. Nat. Rev. Drug Discov.. 2006; 5: 993-996 [OpenAIRE] [PubMed] [DOI]

Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P.. The nuclear receptor superfamily: The second decade. Cell. 1995; 83: 835-839 [OpenAIRE] [PubMed] [DOI]

Li, Y., Lambert, M.H., Xu, H.E.. Activation of nuclear receptors: A perspective from structural genomics. Structure. 2003; 11: 741-746 [PubMed]

Jin, L., Li, Y.. Structural and functional insights into nuclear receptor signaling. Adv. Drug Deliv. Rev.. 2010; 62: 1218-1226 [OpenAIRE] [PubMed] [DOI]

Halilbasic, E., Baghdasaryan, A., Trauner, M.. Nuclear receptors as drug targets in cholestatic liver diseases. Clin. Liver Dis.. 2013; 17: 161-189 [OpenAIRE] [PubMed] [DOI]

Jiang, M., Xie, W.. Role of the constitutive androstane receptor in obesity and type 2 diabetes: A case study of the endobiotic function of a xenobiotic receptor. Drug Metab. Rev.. 2013; 45: 156-163 [OpenAIRE] [PubMed] [DOI]

moresidebar