publication . Article . 2018

Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections

Asha, Kumari; Kumar, Prashant; Sanicas, Melvin; Meseko, Clement; Khanna, Madhu; Kumar, Binod;
Open Access English
  • Published: 01 Dec 2018 Journal: Journal of Clinical Medicine, volume 8, issue 1 (issn: 2077-0383, Copyright policy)
  • Publisher: MDPI AG
Several viruses cause pulmonary infections due to their shared tropism with cells of the respiratory tract. These respiratory problems due to viral infection become a public health concern due to rapid transmission through air/aerosols or via direct-indirect contact with infected persons. In addition, the cross-species transmission causes alterations to viral genetic makeup thereby increasing the risk of emergence of pathogens with new and more potent infectivity. With the introduction of effective nucleic acid-based technologies, post translational gene silencing (PTGS) is being increasingly used to silence viral gene targets and has shown promising approach to...
Persistent Identifiers
free text keywords: nucleic acid therapy, siRNA, ribozyme, aptamers, DNAzyme, influenza virus, RSV, SARS-CoV, adenovirus, antiviral drugs, General Medicine, COVID-19 ; aptamers ; DNAzyme ; SARS-CoV ; RSV ; antiviral drugs ; siRNA ; nucleic acid therapy ; ribozyme ; adenovirus ; influenza virus, Review, lcsh:Medicine, lcsh:R, Nucleic acid, Deoxyribozyme, Virus, Tropism, Genetic enhancement, Gene silencing, Respiratory tract, medicine.anatomical_structure, medicine, business.industry, business, Respiratory system, Virology
155 references, page 1 of 11

Khanna, M., Kumar, P., Choudhary, K., Kumar, B., Vijayan, V.K.. Emerging influenza virus: A global threat. J. Biosci.. 2008; 33: 475-482 [OpenAIRE] [PubMed] [DOI]

Khanna, M., Kumar, B., Gupta, A., Kumar, P.. Pandemic Influenza a H1N1 (2009) Virus: Lessons from the Past and Implications for the Future. Indian J. Virol.. 2012; 23: 12-17 [OpenAIRE] [PubMed] [DOI]

Khanna, M., Kumar, B., Gupta, N., Kumar, P., Gupta, A., Vijayan, V.K., Kaur, H.. Pandemic swine influenza virus (H1N1): A threatening evolution. Indian J. Microbiol.. 2009; 49: 365-369 [OpenAIRE] [PubMed] [DOI]

Kumar, B., Asha, K., Khanna, M., Ronsard, L., Meseko, C.A., Sanicas, M.. The emerging influenza virus threat: Status and new prospects for its therapy and control. Arch. Virol.. 2018; 163: 831-844 [OpenAIRE] [PubMed] [DOI]

Riley, S., Fraser, C., Donnelly, C.A., Ghani, A.C., Abu-Raddad, L.J., Hedley, A.J., Leung, G.M., Ho, L.M., Lam, T.H., Thach, T.Q.. Transmission dynamics of the etiological agent of SARS in Hong Kong: Impact of public health interventions. Science. 2003; 300: 1961-1966 [OpenAIRE] [PubMed] [DOI]

Perlman, S., Netland, J.. Coronaviruses post-SARS: Update on replication and pathogenesis. Nat. Rev. Microbiol.. 2009; 7: 439-450 [OpenAIRE] [PubMed] [DOI]

Monne, I., Meseko, C., Joannis, T., Shittu, I., Ahmed, M., Tassoni, L., Fusaro, A., Cattoli, G.. Highly Pathogenic Avian Influenza A(H5N1) Virus in Poultry, Nigeria, 2015. Emerg. Infect. Dis.. 2015; 21: 1275-1277 [OpenAIRE] [PubMed] [DOI]

Meseko, C., Globig, A., Ijomanta, J., Joannis, T., Nwosuh, C., Shamaki, D., Harder, T., Hoffman, D., Pohlmann, A., Beer, M.. Evidence of exposure of domestic pigs to Highly Pathogenic Avian Influenza H5N1 in Nigeria. Sci. Rep.. 2018; 8: 5900 [OpenAIRE] [PubMed] [DOI]

Fasina, F.O., Bisschop, S.P., Ibironke, A.A., Meseko, C.A.. Avian influenza risk perception among poultry workers, Nigeria. Emerg. Infect. Dis.. 2009; 15: 616-617 [OpenAIRE] [PubMed] [DOI]

Khanna, M., Sharma, S., Kumar, B., Rajput, R.. Protective immunity based on the conserved hemagglutinin stalk domain and its prospects for universal influenza vaccine development. BioMed Res. Int.. 2014; 2014: 546274 [OpenAIRE] [PubMed] [DOI]

Dudas, R.A., Karron, R.A.. Respiratory syncytial virus vaccines. Clin. Microbiol. Rev.. 1998; 11: 430-439 [OpenAIRE] [PubMed] [DOI]

Gewirtz, A.M., Sokol, D.L., Ratajczak, M.Z.. Nucleic acid therapeutics: State of the art and future prospects. Blood. 1998; 92: 712-736 [PubMed]

Merdan, T., Kopecek, J., Kissel, T.. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Deliv. Rev.. 2002; 54: 715-758 [OpenAIRE] [PubMed] [DOI]

Shi, N., Zhang, Y., Zhu, C., Boado, R.J., Pardridge, W.M.. Brain-specific expression of an exogenous gene after I.V. administration. Proc. Natl. Acad. Sci. USA. 2001; 98: 12754-12759 [OpenAIRE] [PubMed] [DOI]

Ehsan, A., Mann, M.J., Dell’Acqua, G., Dzau, V.J.. Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. J. Thorac. Cardiovasc. Surg.. 2001; 121: 714-722 [OpenAIRE] [PubMed] [DOI]

155 references, page 1 of 11
Any information missing or wrong?Report an Issue