publication . Article . 2018

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Dey, Tapan; Kalita, Jatin; Weldon, Sinéad; Taggart, Clifford;
Open Access English
  • Published: 28 Aug 2018 Journal: Journal of Clinical Medicine, volume 7, issue 9 (eissn: 2077-0383, Copyright policy)
  • Publisher: MDPI
  • Country: United Kingdom
In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.
Persistent Identifiers
Sustainable Development Goals (SDG) [Beta]
Medical Subject Headings: respiratory tract diseases
free text keywords: Review, chronic obstructive pulmonary disease, protease, antiprotease, General Medicine, Intensive care medicine, medicine.medical_specialty, medicine, business.industry, business, Respiratory disease, medicine.disease, COPD, Proteases, Drug development, Lung, medicine.anatomical_structure, Disease, Context (language use), Drug, media_common.quotation_subject, media_common, lcsh:Medicine, lcsh:R
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