publication . Article . 2018

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Dey, Tapan; Kalita, Jatin; Weldon, Sinéad; Taggart, Clifford;
Open Access English
  • Published: 28 Aug 2018 Journal: Journal of Clinical Medicine, volume 7, issue 9 (eissn: 2077-0383, Copyright policy)
  • Publisher: MDPI
  • Country: United Kingdom
Abstract
In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.
Persistent Identifiers
Sustainable Development Goals (SDG) [Beta]
Subjects
Medical Subject Headings: respiratory tract diseases
free text keywords: Review, chronic obstructive pulmonary disease, protease, antiprotease, General Medicine, Intensive care medicine, medicine.medical_specialty, medicine, business.industry, business, Respiratory disease, medicine.disease, COPD, Proteases, Drug development, Lung, medicine.anatomical_structure, Disease, Context (language use), Drug, media_common.quotation_subject, media_common, lcsh:Medicine, lcsh:R
170 references, page 1 of 12

Lopez, A.D., Shibuya, K., Rao, C., Mathers, C.D., Hansell, A.L., Held, L.S., Schmid, V., Buist, S.. Chronic obstructive pulmonary disease: Current burden and future projections. Eur. Respir. J.. 2006; 27: 397-412 [OpenAIRE] [PubMed] [DOI]

World Health Organization Report: Burden of Chronic Respiratory Disease. 2011

Dalal, A.A., Christensen, L., Liu, F., Riedel, A.A.. Direct costs of chronic obstructive pulmonary disease among managed care patients. Int. J. Chron. Obstr. Pulm. Dis.. 2010; 5: 341-349 [OpenAIRE] [PubMed] [DOI]

Bhome, A.B.. COPD in India: Iceberg or volcano?. J. Thorac. Dis.. 2012; 4: 298-309 [OpenAIRE] [PubMed]

Chen, X., Wang, N., Chen, Y., Xiao, T., Fu, C., Xu, B.. Costs of chronic obstructive pulmonary disease in urban areas of China: A cross-sectional study in four cities. Int. J. Chron. Obstr. Pulm. Dis.. 2016; 11: 2625-2632 [OpenAIRE] [PubMed] [DOI]

Adeloye, D., Chua, S., Lee, C., Basquill, C., Papana, A., Theodoratou, E., Nair, H., Gasevic, D., Sridhar, D., Campbell, H.. Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J. Glob. Health. 2015; 5: 020415 [OpenAIRE] [PubMed] [DOI]

Nowak, D., Berger, K., Lippert, B., Kilgert, K., Caeser, M., Sandtmann, R.. Epidemiology and health economics of COPD across Europe: A critical analysis. Treat. Respir. Med.. 2005; 4: 381-395 [OpenAIRE] [PubMed] [DOI]

Lahousse, L., Seys, L.J.M., Joos, G.F., Franco, O.H., Stricker, B.H., Brusselle, G.G.. Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease. Eur. Respir. J.. 2017; 50: 1602470 [OpenAIRE] [PubMed] [DOI]

Sharafkhaneh, A., Hanania, N.A., Kim, V.. Pathogenesis of emphysema: From the bench to the bedside. Proc. Am. Thorac. Soc.. 2008; 5: 475-477 [OpenAIRE] [PubMed] [DOI]

Kamal, R., Srivastava, A.K., Kesavachandran, C.N.. Meta-analysis approach to study the prevalence of chronic obstructive pulmonary disease among current, former and non-smokers. Toxicol. Rep.. 2015; 2: 1064-1074 [OpenAIRE] [PubMed] [DOI]

Tashkin, D.P., Murray, R.P.. Smoking cessation in chronic obstructive pulmonary disease. Respir. Med.. 2009; 103: 963-974 [OpenAIRE] [PubMed] [DOI]

Brode, S.K., Ling, S.C., Chapman, K.R.. Alpha-1 antitrypsin deficiency: A commonly overlooked cause of lung disease. CMAJ. 2012; 184: 1365-1371 [OpenAIRE] [PubMed] [DOI]

DeMeo, D.L., Silverman, E.K.. Alpha1-antitrypsin deficiency. 2: Genetic aspects of alpha(1)-antitrypsin deficiency: Phenotypes and genetic modifiers of emphysema risk. Thorax. 2004; 59: 259-264 [OpenAIRE] [PubMed] [DOI]

Fukuchi, Y.. The aging lung and chronic obstructive pulmonary disease: Similarity and difference. Proc. Am. Thorac. Soc.. 2009; 6: 570-572 [PubMed] [DOI]

Lowery, E.M., Brubaker, A.L., Kuhlmann, E., Kovacs, E.J.. The aging lung. Clin. Interv. Aging. 2013; 8: 1489-1496 [OpenAIRE] [PubMed]

170 references, page 1 of 12
Any information missing or wrong?Report an Issue