With the current advance of technology, agent-based applications are becoming a standard in a great variety of domains such as e-commerce, logistics, supply chain management, telecommunications, healthcare, and manufacturing. Another reason for the widespread interest in multi-agent systems is that these systems are seen as a technology and a tool that helps in the analysis and development of new models and theories in large-scale distributed systems or in human-centered systems. This last aspect is currently of great interest due to the need for democratization in the use of technology that allows people without technical preparation to interact with the devices in a simple and coherent way. In this Special Issue, different interesting approaches that advance this research discipline have been selected and presented.