In a multi-agent system, the complex interaction among agents is one of the difficulties in making the optimal decision. This paper proposes a new action value function and a learning mechanism based on the optimal equivalent action of the neighborhood (OEAN) of a multi-agent system, in order to obtain the optimal decision from the agents. In the new Q-value function, the OEAN is used to depict the equivalent interaction between the current agent and the others. To deal with the non-stationary environment when agents act, the OEAN of the current agent is inferred simultaneously by the maximum a posteriori based on the hidden Markov random field model. The convergence property of the proposed methodology proved that the Q-value function can approach the global Nash equilibrium value using the iteration mechanism. The effectiveness of the method is verified by the case study of the top-coal caving. The experiment results show that the OEAN can reduce the complexity of the agents’ interaction description, meanwhile, the top-coal caving performance can be improved significantly.