Actions
  • shareshare
  • link
  • cite
  • add
add
auto_awesome_motion View all 11 versions
Publication . Article . Other literature type . 2019

Molecular Targets for Coevolutionary Interactions Between Pacific Oyster Larvae and Their Sympatric Vibrios

K. Mathias Wegner; Damien Piel; Damien Piel; Maxime Bruto; Uwe John; Uwe John; Zhijuan Mao; +6 Authors
Open Access
English
Published: 06 Sep 2019
Publisher: HAL CCSD
Abstract

International audience; Bacteria of the Vibrio genus are the most predominant infectious agents threatening marine wildlife and aquaculture. Due to the large genetic diversity of these pathogens, the molecular determinants of Vibrio virulence are only poorly understood. Furthermore, studies tend to ignore co-evolutionary interactions between different host populations and their locally encountered Vibrio communities. Here, we explore the molecular targets of such co-evolutionary interactions by analyzing the genomes of nine Vibrio strains from the Splendidus-clade showing opposite virulence patterns towards two populations of Pacific oysters introduced into European Wadden Sea. By contrasting Vibrio phylogeny to their host specific virulence patterns, we could identify two core genome genes (OG1907 and OG 3159) that determine the genotype by genotype (G × G) interactions between oyster larvae and their sympatric Vibrio communities. Both genes show positive selection between locations targeting only few amino acid positions. Deletion of each gene led to a loss of the host specific virulence patterns while complementation with OG3159 alleles from both locations could recreate the wild type phenotypes matching the origin of the allele. This indicates that both genes can act as a genetic switch for Vibrio-oyster coevolution demonstrating that local adaptation in distinct Vibrio lineages can rely on only few genes independent of larger pathogenicity islands or plasmids.

Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:Microbiology lcsh:QR1-502

Microsoft Academic Graph classification: Genotype Genetic diversity Vibrio biology.organism_classification biology Pacific oyster Pathogenicity island Host–pathogen interaction Genetics Virulence Sympatric speciation

Subjects

ACL, host-pathogen interaction, Wadden Sea, emerging disease, biological invasion, local adaptation, virulence, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Microbiology, Original Research, Microbiology (medical), virulence, host-pathogen interaction, local adaptation, biological invasion, emerging disease, Wadden Sea

Funded by
ANR| REVENGE
Project
REVENGE
OYSTER AS A NICHE FOR VIBRIO EVOLUTION AND PATHOGEN EMERGENCE
  • Funder: French National Research Agency (ANR) (ANR)
  • Project Code: ANR-16-CE32-0008
Download fromView all 8 sources
lock_open
DOAJ-Articles
Article . 2019
Providers: DOAJ-Articles
moresidebar