publication . Other literature type . Article . 2017

Cytokine Profiles of Severe Influenza Virus-Related Complications in Children

Fiore-Gartland, Andrew; Panoskaltsis-Mortari, Angela; Agan, Anna A.; Mistry, Anushay J.; Thomas, Paul G.; Matthay, Michael A.; Sanders, Ronald C.; Hertz, Tomer; Randolph, Adrienne G.;
Open Access
  • Published: 06 Nov 2017
  • Publisher: Frontiers Media SA
  • Country: United States
Abstract
Rationale: Effective immunomodulatory therapies for children with life-threatening “cytokine storm” triggered by acute influenza infection are lacking. Understanding the immune profiles of children progressing to severe lung injury and/or septic shock could provide insight into pathogenesis. Objectives: To compare the endotracheal and serum cytokine profiles of children with influenza-related critical illness and to identify their associations with severe influenza-associated complications. Methods: Children with influenza-related critical illness were enrolled across 32 hospitals in development (N = 171) and validation (N = 73) cohorts (December 2008 through Ma...
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free text keywords: influenza, cytokine, acute lung injury, septic shock, inflammation, Immunology, Inflammation, medicine.symptom, medicine, Lung injury, Interleukin 10, Septic shock, medicine.disease, Pathogenesis, Cytokine storm, Cytokine, medicine.medical_treatment, business.industry, business, Coinfection
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