Abstract THE association of Solanum malacoxylon with bovine arteriosclerosis in Argentina (Worker and Carrillo, 1967) suggested that a similar condition in Hawaiian cattle, known as “Naalehu disease” (Lynd et al., 1965), might be caused by a related plant, Solanum sodomaeum, which grows in the area where this disease is endemic. The toxicity of the dried fruit of S. sodomaeum to Japanese quail and White Leghorn chicks has been described by Ross and Furumoto (1970). The research reported herein was conducted to compare the effects of both species of Solanum on chicks and to study some of the metabolic changes in more detail. MATERIALS AND METHODS In all three experiments day-old S.C.W.L. male chicks were reared in groups of ten in heated battery brooders with raised wire floors. Quadruplicate groups per treatment were used in experiment 1, triplicate groups in experiment 2 and duplicate groups in experiment 3. Experiment 2 and 3…