Deleuze's ethics constitutes the core of his philosophy, which proposes a post-humanistic but robust nomadic vision of the subject that respects the complexity of our times while avoiding the pitfalls of postmodern and other forms of relativism. Deleuze's neo-Spinozist ethics rests on an active relational ontology that looks for the ways in which otherness prompts, mobilises and allows for flows of affirmation of values and forces which are not yet sustained by the current conditions. Insofar as the conditions need to be brought about or actualised by collective efforts to induce qualitative transformations in our interactions, it requires the praxis of affirmative ethics. The process of becoming-minor, which necessarily involves becoming-woman, is central to this pragmatic ethical project that includes human as well as non-human actors. This paper addresses this ethics in terms of ontological relationality, affectivity and endurance.