SummaryThe effect of hypophysectomy on feed consumption in the rat was determined by two methods. A reduction was observed when operated rats were compared with sham-operated controls, and the feed consumption of the same rats before and after the operation was compared.The two methods indicated that hypophysectomy reduced the mean daily feed intake about 30%: These results are quite similar to the observation that the combined operations of thyroidectomy and adrenalectomy reduced feed intake about 30%, indicating that the lack of thyroxine and corticosterone may be the major hormones concerned in feed intake of those secreted by the pituitary and its target glands.