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Toxina botulínica tipo A en el tratamiento de sialorrea en pacientes con enfermedad de Parkinson

Authors: Alma Yolanda Alvarado-Gutiérrez; Jorge Hernández-Franco; Israel Sánchez-Villavicencio;

Toxina botulínica tipo A en el tratamiento de sialorrea en pacientes con enfermedad de Parkinson

Abstract

La sialorrea se define como exceso de saliva en la boca que rebasa el margen de los labios. Es patologica la inyección de toxina botulínica tipo A pareciera ser la más segura pues ofrece un rango de efectividad de hasta 3 meses. Objetivos: estudiar si a dosis bajas (75 unidades) de abobotoxina tipo en la glándula parótida de pacientes con enfermedad de Parkinson y sialorrea, es efectiva sin presencia de efectos adversos. Material y métodos: estudio transversal, descriptivo en pacientes con la escala sialorrea clinical scale for Parkinson disease (SCS-PD), de severidad y frecuencia para salivación (DSFS), tiempo de ingreso al estudio y a las semanas 1, 2, 4, 8, 12, 16. Resultados: se incluyeron 6 pacientes, con una media de edad de 67.3 años, 11.8 años de media de padecer Parkinson, 4 años de padecer sialorrea. El análisis de la disminución de un score global para SCS-PD desde el basal hasta la semana 12, presenta significancia estadística (p=0.0030) corroborando así el efecto benéfico de la toxina; por lo menos, durante 3 meses. Conclusiones: una dosis de 75 unidades de abobotoxina tipo A pareciera ser adecuado para el control del síntoma sin crear efectos adversos indeseables que comienza desde la primera semana de la aplicación manteniéndose hasta 3 meses de inicio del tratamiento.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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