publication . Article . 2020

Preclinical in vivo Neurotoxicity Studies of Drug Candidates

N. V. Eremina; L. G. Kolik; R. U. Ostrovskaya; A. D. Durnev;
Open Access
  • Published: 18 Sep 2020 Journal: The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products, volume 10, pages 164-176 (issn: 1991-2919, eissn: 2619-1172, Copyright policy)
  • Publisher: SCEEMP
Abstract
<jats:p>Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity. Current experimental approaches to neurotoxicity assessment are cumbersome, laborious and not adapted enough for preclinical studies in the early stages of drug development. The aim of the study was to review existing approaches to experimental assessment of neurotoxic potential of new drugs and to discuss the need for and feasibility of developing and using integrated rapid neurotoxicity tests for early assessment of a pharma...
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free text keywords: neurotoxicity, preclinical studies, irwin tests, functional observational battery, cognitive studies, mice, rats, Cognition, Current practice, Neuroscience, In vivo, Guidance documents, Neurotoxic Disorders, Neurotoxicity, medicine.disease, medicine, Drug development, business.industry, business, lcsh:Medicine (General), lcsh:R5-920
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