publication . Other literature type . Article . 2019

New Anticonvulsants: Interchangeability Issues and the Use of Generic Anticonvulsants in Clinical Practice

Arkhipov, V. V.; Sokova, E. A.; Gorodetskaya, G. I.; Demidova, O. A.; Aleksandrova, T. V.;
Open Access
  • Published: 05 Jun 2019
  • Publisher: SCEEMP
Abstract
<jats:p>This article looks into interchangeability and therapeutic equivalence of innovator and generic anticonvulsants — the first-generation and new antiepileptic drugs (AEDs). The results of a number of clinical trials assessing therapeutic equivalence of generic AEDs support the opinion that these medicines could only be substituted provided an ultra-cautious approach is used, even if the case involves only one International Nonproprietary Name, including, but not limited to different dosage forms of one and the same product. The aim of the study was to analyse factors leading to incorrect assessment of therapeutic equivalence of new and generic anticonvulsa...
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Subjects
free text keywords: anticonvulsants, interchangeability, therapeutic equivalence, generics, clinical studies, efficacy, safety, lcsh:Medicine (General), lcsh:R5-920
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