publication . Article . 2019

Criteria for Evaluation of Clinical Efficacy of Anticancer Medicines

Tikhomirova, A. V.;
Open Access
  • Published: 25 Mar 2019 Journal: The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products, volume 9, pages 34-40 (issn: 1991-2919, eissn: 2619-1172, Copyright policy)
  • Publisher: SCEEMP
Abstract
Criteria for evaluation of clinical efficacy make it possible to assess the risk-benefit ratio of anticancer medicines that patients receive, in particular, for the treatment of solid malignant tumors. A medicine’s efficacy is assessed using special criteria called the endpoints of clinical efficacy, allowing most objective assessment of study results. It was demonstrated that nowadays clinical efficacy of anticancer drugs is assessed using «patient-centered» (overall survival and quality of life) and «tumor-centered» (response to therapy, progression-free survival, disease-free survival) endpoints. «Patient-centered» endpoints make it possible to evaluate the d...
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free text keywords: endpoints, clinical efficacy, survival, objective response, subjective response, quality of life, anticancer medicines, Medicine (General), R5-920, Outcome measures, Quality of life, In patient, Objective assessment, Clinical efficacy, Medicine, business.industry, business, Overall survival, Intensive care medicine, medicine.medical_specialty, Clinical endpoint, Disease
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