publication . Article . 2018

X-RAY POWDER DIFFRACTION IN QUALITY CONTROL OF MEDICINES

Kuzmin, V. S.; Chernyshev, V. V.; Luttseva, A. I.;
Open Access
  • Published: 26 Sep 2018 Journal: The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products, volume 8, pages 158-161 (issn: 1991-2919, Copyright policy)
  • Publisher: SCEEMP
Abstract
X-ray powder diffraction is one of the methods used for detection and analysis of polymorphic forms of pharmaceutical substances. The article elucidates the concept of polymorphism, briefly explains physical characteristics of this phenomenon, conditions of polymorphic transformations and the prevalence of polymorphic forms among drug substances. It should be noted that polymorphism is observed in drug substances belonging to different pharmacologic classes. Polymorphic forms of the same drug substance have different solubility, melting point, resistance to oxidation and to other destructive processes, and, consequently, different surface properties which affect...
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free text keywords: quality control, polymorphism, polymorphic forms, x-ray diffraction analysis, phenazepam, tilorone, fabomotizole, zolendronic acid, dehydroepiandrosterone, Medicine (General), R5-920, Tilorone, medicine.drug, medicine, Phenazepam, Melting point, Solubility, Powder diffraction, Organic chemistry, Drug, media_common.quotation_subject, media_common, Dosage form, Biological activity, Chemistry
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